SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
Identifieur interne : 000409 ( Main/Exploration ); précédent : 000408; suivant : 000410SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes
Auteurs : Leslie Calapre ; Elin S. Gray ; Sandrine Kurdykowski [France] ; Anthony David [France] ; Pascal Descargues [France] ; Mel ZimanSource :
- BMC Dermatology [ 1471-5945 ] ; 2017.
Abstract
Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB
Activation of SIRT1 after multiple UVB
This study demonstrate that heat-induced SIRT1 activation mediates survival of DNA damaged keratinocytes through deacetylation of p53 after exposure to UVB
The online version of this article (doi:10.1186/s12895-017-0060-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12895-017-0060-y
PubMed: 28601088
PubMed Central: 5466784
Affiliations:
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type="main">SIRT1 activation mediates heat-induced survival of UVB damaged Keratinocytes</title><author><name sortKey="Calapre, Leslie" sort="Calapre, Leslie" uniqKey="Calapre L" first="Leslie" last="Calapre">Leslie Calapre</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4302</institution-id><institution-id institution-id-type="GRID">grid.1038.a</institution-id><institution>School of Medical Science,</institution><institution>Edith Cowan University,</institution></institution-wrap>270 Joondalup Drive, Joondalup, Perth, WA 6027 Australia</nlm:aff><wicri:noCountry code="subfield">WA 6027 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Gray, Elin S" sort="Gray, Elin S" uniqKey="Gray E" first="Elin S." last="Gray">Elin S. Gray</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4302</institution-id><institution-id institution-id-type="GRID">grid.1038.a</institution-id><institution>School of Medical Science,</institution><institution>Edith Cowan University,</institution></institution-wrap>270 Joondalup Drive, Joondalup, Perth, WA 6027 Australia</nlm:aff><wicri:noCountry code="subfield">WA 6027 Australia</wicri:noCountry></affiliation></author><author><name sortKey="Kurdykowski, Sandrine" sort="Kurdykowski, Sandrine" uniqKey="Kurdykowski S" first="Sandrine" last="Kurdykowski">Sandrine Kurdykowski</name><affiliation wicri:level="3"><nlm:aff id="Aff2">GENOSKIN Centre Pierre Potier, Oncopole, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>GENOSKIN Centre Pierre Potier, Oncopole, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="David, Anthony" sort="David, Anthony" uniqKey="David A" first="Anthony" last="David">Anthony David</name><affiliation wicri:level="3"><nlm:aff id="Aff2">GENOSKIN Centre Pierre Potier, Oncopole, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>GENOSKIN Centre Pierre Potier, Oncopole, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Descargues, Pascal" sort="Descargues, Pascal" uniqKey="Descargues P" first="Pascal" last="Descargues">Pascal Descargues</name><affiliation wicri:level="3"><nlm:aff id="Aff2">GENOSKIN Centre Pierre Potier, Oncopole, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>GENOSKIN Centre Pierre Potier, Oncopole, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Ziman, Mel" sort="Ziman, Mel" uniqKey="Ziman M" first="Mel" last="Ziman">Mel Ziman</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0389 4302</institution-id><institution-id institution-id-type="GRID">grid.1038.a</institution-id><institution>School of Medical Science,</institution><institution>Edith Cowan University,</institution></institution-wrap>270 Joondalup Drive, Joondalup, Perth, WA 6027 Australia</nlm:aff><wicri:noCountry code="subfield">WA 6027 Australia</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7910</institution-id><institution-id institution-id-type="GRID">grid.1012.2</institution-id><institution>School of Pathology and Laboratory Medicine,</institution><institution>University of Western Australia,</institution></institution-wrap>Crawley, WA Australia</nlm:aff><wicri:noCountry code="subfield">WA Australia</wicri:noCountry></affiliation></author></analytic><series><title level="j">BMC Dermatology</title><idno type="eISSN">1471-5945</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB <italic>plus</italic> heat exposed keratinocytes.</p></sec><sec><title>Results</title><p>Activation of SIRT1 after multiple UVB <italic>plus</italic> heat exposures resulted in increased p53 deacetylation at K382, which is known to affect its binding to specific target genes. Accordingly, we noted decreased apoptosis and down regulation of the p53 targeted pro-apoptotic gene <italic>BAX</italic> and the DNA repair genes <italic>ERCC1</italic> and <italic>XPC</italic> after UVB <italic>plus</italic> heat treatments. In addition, UVB <italic>plus</italic> heat induced increased expression of the cell survival gene <italic>Survivin</italic> and the proliferation marker Ki67. Notably, keratinocytes exposed to UVB <italic>plus</italic> heat in the presence of the SIRT1 inhibitor, Ex-527, showed a similar phenotype to those exposed to UV alone; i.e. an increase in p53 acetylation, increased apoptosis and low levels of <italic>Survivin</italic>.</p></sec><sec><title>Conclusion</title><p>This study demonstrate that heat-induced SIRT1 activation mediates survival of DNA damaged keratinocytes through deacetylation of p53 after exposure to UVB <italic>plus</italic> heat</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s12895-017-0060-y) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Madan, V" uniqKey="Madan V">V Madan</name></author><author><name sortKey="Lear, Jt" uniqKey="Lear J">JT Lear</name></author><author><name sortKey="Szeimies, Rm" uniqKey="Szeimies R">RM 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Wedge</name></author><author><name sortKey="Fullam, A" uniqKey="Fullam A">A Fullam</name></author><author><name sortKey="Alexandrov, Lb" uniqKey="Alexandrov L">LB Alexandrov</name></author><author><name sortKey="Tubio, Jm" uniqKey="Tubio J">JM Tubio</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement></list><tree><noCountry><name sortKey="Calapre, Leslie" sort="Calapre, Leslie" uniqKey="Calapre L" first="Leslie" last="Calapre">Leslie Calapre</name><name sortKey="Gray, Elin S" sort="Gray, Elin S" uniqKey="Gray E" first="Elin S." last="Gray">Elin S. Gray</name><name sortKey="Ziman, Mel" sort="Ziman, Mel" uniqKey="Ziman M" first="Mel" last="Ziman">Mel Ziman</name></noCountry><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Kurdykowski, Sandrine" sort="Kurdykowski, Sandrine" uniqKey="Kurdykowski S" first="Sandrine" last="Kurdykowski">Sandrine Kurdykowski</name></region><name sortKey="David, Anthony" sort="David, Anthony" uniqKey="David A" first="Anthony" last="David">Anthony David</name><name sortKey="Descargues, Pascal" sort="Descargues, Pascal" uniqKey="Descargues P" first="Pascal" last="Descargues">Pascal Descargues</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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